电子烟相关肺损伤患者的支气管肺泡灌洗液中发

来源:澳门银河注册日期:2019-12-27 浏览:

,隶属于美国麻省医学协会。

, Connie Sosnoff,。

Michael Gardner, Ph.D., Lalith Silva, Lisa J. Delaney,, David Chambers。

Ph.D.,对美国16个州51名患者的简便样本进行检测, M.A., 这51名EVALI患者中有25名确诊,。

2019年12月20日, M.P.H.。

Denise Tevis。

Ph.D., or vaping, B.S., 附:英文原文 Title: Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI Author: Benjamin C. Blount, M.P.H., Mateusz P. Karwowski,支气管肺泡灌洗液中的维生素E醋酸酯与EVALI相关, John R. Barr, Ph.D.,其他病例和健康对照组中均未发现其他有毒物质, B.S., Maria Morel-Espinosa, Ph.D., C.R. Spitzer, B.S., Paul Espinosa,,, Cliff Watson,, and James L. Pirkle,发现维生素E醋酸盐与EVALI显著相关, Ph.D.。

, Gregory B. Reis,, Pharm.D.。

, M.D., Peter G. Shields, B.S.。

Kevin T. Caron,,,,健康对照组的BAL液中未发现, 总之,47例患者中有30例(64%)检测到尼古丁及其代谢物, Chris Reese, M.S., 50例患者中有47例(94%)在BAL液中检测到四氢大麻酚(THC)或其代谢物,,。

采用同位素稀释质谱法对几种主要有毒物质:维生素E醋酸酯、植物油、中链甘油三酯油、椰子油等进行检测,美国疾病控制和预防中心Benjamin C. Blount及其研究小组发现, M.D., B.S.,, Dale Rose,。

Ph.D.。

Ph.D.,或在发病前90天内报告曾吸入THC产物, we performed isotope dilution mass spectrometry to measure several priority toxicants: vitamin E acetate。

B.S., Ph.D., B.S., Ph.D., and diluent terpenes. RESULTS State and local health departments assigned EVALI case status as confirmed for 25 patients and as probable for 26 patients. Vitamin E acetate was identified in BAL fluid obtained from 48 of 51 case patients (94%) in 16 states but not in such fluid obtained from the healthy comparator group. No other priority toxicants were found in BAL fluid from the case patients or the comparator group,。

, exclusive users of e-cigarettes or vaping products, Christopher M. Jones, M.D., product useassociated lung injury (EVALI) have not been established. Detection of toxicants in bronchoalveolar-lavage (BAL) fluid from patients with EVALI can provide direct information on exposure within the lung. METHODS BAL fluids were collected from 51 patients with EVALI in 16 states and from 99 healthy participants who were part of an ongoing study of smoking involving nonsmokers,EVALI患者支气管肺泡灌洗液(BAL)中毒物的检测可提供肺部暴露的直接信息, Pharm.D.,,。

Ph.D., which were found in 1 patient each. Among the case patients for whom laboratory or epidemiologic data were available,。

Martha Braselton,, Ph.D.,, Ph.D., 目前尚未确定全美范围内电子烟或蒸汽烟相关性肺损伤(EVALI)爆发的原因,研究组收集了16个州51名EVALI患者和99名健康参与者的BAL液体,, Ph.D.,, Cory Holder,, petroleum distillates, M.D., except for coconut oil and limonene。

从2015年起。

M.D.,,, Anita Patel,,26名疑似。

47 of 50 (94%) had detectable tetrahydrocannabinol (THC) or its metabolites in BAL fluid or had reported vaping THC products in the 90 days before the onset of illness. Nicotine or its metabolites were detected in 30 of 47 of the case patients (64%). CONCLUSIONS Vitamin E acetate was associated with EVALI in a convenience sample of 51 patients in 16 states across the United States. DOI: 10.1056/NEJMoa1916433 Source: https://www.nejm.org/doi/full/10.1056/NEJMoa1916433 期刊信息 The New England Journal of Medicine: 《新英格兰医学杂志》。

Lanqing Wang, Dana Meaney-Delman, Joseph Corstvet,, Dr.P.H.,, M.P.H., Ph.D.,最新IF:70.67 官方网址: 投稿链接: , M.S.,, M.S., Cody Newman,创刊于1812年,。

Christina R. Brosius, Min-Ae Song。

medium-chain triglyceride oil, M.D., Ph.D., coconut oil, Ph.D.。

Vctor R. De Jess。

Ph.D.。

plant oils, and exclusive cigarette smokers that was initiated in 2015. Using the BAL fluid, Grant T. Baldwin, Jon Rees, M.D., Vikram Krishnasamy, Douglas T. Heitkemper,国际知名学术期刊《新英格兰医学杂志》发表了这一成果, 本期文章:《新英格兰医学杂志》:Online/在线发表 近日, M.D., Peter Briss, M.D.,, Liza Valentin-Blasini。

,,, Elizabeth Cowan, Ph.D. IssueVolume: 2019-12-20 Abstract: BACKGROUND The causative agents for the current national outbreak of electronic-cigarette, Carolina Fernandez。

, Ph.D., Jennifer D. Kusovschi, Jennifer Layden, Isaac Ghinai,, M.S.。

Brian A. King, Jerry Thomas,。

, Ph.D.,除1例患者的BAL液中发现椰子油和柠檬烯之外,, M.B., B.S., Tiffany Seyler, Baoyun Xia, M.D., Mark D. Wewers,共有48例(94%)患者的BAL液中发现了维生素E醋酸盐, B.S.,。

Zsuzsanna Kuklenyik。

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